Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1078 | Neuroendocrinology | ICEECE2012

The limited screening value of insulin-like growth factor-I as a marker for alterations in body composition in very long term adult survivors of childhood cancer

Blijdorp K. , Heuvel M. Van den , Pieters R. , Lely A. Van der , Neggers S.

Introduction: The clinical relevance of low IGF-I levels, caused by cranial radiotherapy, in adult childhood cancer survivors has not been studied extensively. We evaluated whether IGF-I is a useful marker for altered body composition and growth hormone deficiency in this group.Methods: We analyzed retrospective data from 610 adult childhood cancer survivors, retrieved from the late effects clinic. Median age at diagnosis was 6 years (interquartile range...

ea0029p1175 | Obesity | ICEECE2012

Longitudinal changes in body mass index and body composition among 417 adult survivors of childhood cancer

Blijdorp K. , van den Heuvel M. , Pieters R. , Boot A. , van der Lelij A. , Neggers S.

Introduction: Obesity, represented by high body mass index (BMI), is a major complication after treatment for childhood cancer. High amount of total and visceral fat and low lean body mass are described as more reliable determinants, predicting the development of cardiovascular disease. In this study longitudinal changes of BMI and body composition in adult childhood cancer survivors were evaluated.Methods: Data of 417 adult childhood cancer survivors, w...

ea0029p13 | Adrenal cortex | ICEECE2012

Influence of unilateral adrenalectomy on set point of Hypothalamic-pituitary-adrenal-axis in long-term survivors of childhood nephroblastoma and neuroblastoma

van Waas M. , Pieters R. , Van Noesel M. , Van der Lely A. , De Jong F. , van den Heuvel M. , Neggers S.

Introduction: Adrenal insufficiency, or relative insufficiency, might partly explain increased mortality rates in nephroblastoma and neuroblastoma survivors after unilateral adrenalectomy. Aim of this study was to assess adrenal function and its metabolic effects after unilateral adrenalectomy.Patients and Methods: Cross-sectional study with a socio-demographically similar control group, conducted between October 2009-March 2011 at the Erasmus University...